PubMed · 1990 · 16 citations · 0 references
Autoimmune DiseaseAllergyImmunodeficienciesPathogenesisDr7 AntigensGastroenterologyPediatricsPathologySpecificity Dqw2AutoimmunityClinical PresentationDq SubregionHla TypingCeliac DiseaseMedicineInborn Error Of ImmunityEpidemiology
A population of 62 unrelated homogeneous Argentinian celiac pediatric patients were typed for HLA-A,B,C,DR, and DQ antigens. The association between celiac disease and the DR3 and DR7 antigens was confirmed. The specificity DQw2 was present in 95.2 per cent of the patients. Nevertheless, it was of interest that the most significant phenotypes observed were DR3/DR7, DR7/DR5, and DR3/DR5. The significance of these findings is discussed.