Bone marrow transplantation in congenital immunodeficiency diseases.

Abstract

Bone Marrow transplantation (BMT) is the treatment of choice in a large number of primary immunodeficiencies, for which this treatment is potentially curative. BMT needs to be considered as soon as possible after diagnosis because these disorders usually run an unpredictable course and may be rapidly fatal. Beside conventional HLA-matched donor BMT, there is growing and increasingly favourable experience with alternative, in particular HLA-haploidentical donors. In this review, current results of BMT are presented.