PubMed · 1999 · 18 citations · 0 references
MedicineGeneticsMolecular GeneticsCardiovascular GeneticsEndocrine GeneticsMedical GeneticsCardiovascular DiseaseGenetic RiskHypertensive Heart DiseaseBlood Pressure GeneticsCardiovascular PhenotypingCorrelation AnalysisGenetic Determinants Of HypertensionGenetic Risk MarkersHypertension-related Cardiac RiskInbred Strain GeneticsRecombinant Inbred Lines
The HXB/Ipcv and BXH/Cub sets of recombinant inbred (RI) strains were derived from the spontaneously hypertensive rats (SHR/OlaIpcv) and normotensive Brown Norway (BN-Lx/Cub) rats. The RI strains were produced as a model system for genetic and correlation analysis of spontaneous hypertension and other risk factors of cardiovascular disease such as insulin resistance and dyslipidemia. The RI strains were phenotyped in multiple hemodynamic and metabolic traits. In the current study, we describe strain distribution patterns of 632 genetic markers.