Synthesis of a New Polyfunctionalised Pyrimidine-4-carboxylate and Its Application for the Construction of a Series of Pyrimidine Derivatives

Abstract

The synthesis of a new and versatile polyfunctionalised pyrimidine-4-carboxylate, along with the study of its reactivity against 1,2-dinucleophiles and 1,4-dinucleophiles, is reported. These simple and efficient methodologies allowed for the synthesis of novel pyrimidine derivatives such as pyrimido[4,5-<i>d</i>]pyridazin-8-one-5-carboxylates and their corresponding carbohydrazides and <i>N</i>-acylhydrazone (NAH) derivatives, pyrimido[4,5-<i>d</i>][1,2]oxazin-8-one and its corresponding carbohydrazide derivative, and 3-pyrimidinylquinoxaline-2-one and its corresponding carbohydrazide. Furthermore, pyrimidine hydroxyimino derivatives were also prepared.