EXTRACTION, IDENTIFICATION, FORMULATION AND EVALUATION OF PIPERINE IN ALGINATE BEADS.

Abstract

Piperine {[1-5-(1, 3)-benzodioxol-5-yl)-1-oxo-2, 4-pentadienyl]-piperidine},an alkaloid responsible for the pungency of black pepper & long pepper. Systemic pharmacological studies on piperine have revealed that this compound elicited diverse pharmacological activities; analgesic, anti-pyretic, anti-inflammatory, anti-convulsant & CNS-depressant activities. Piperine was isolated from Piper nigrum Linn. (Piperaceae) and identified by TLC. Piperine was fabricated into alginate beads using sodium alignate. The main aim of this study was to demonstrate the sustained release of piperine from alginate beads by in vitro evaluation. The drug release studies were showed that the alginate beads sustained the release of the drug with % drug released in hours.