PubMed · 2006 · 61 citations · 11 references
MedicineOncologySurgeryGastroenterologyGastrointestinal OncologySurgical OncologyAbdominal SurgeryEmergency LaparotomyGastrointestinal NeoplasmsGastrointestinal PathologyGastrointestinal Stromal TumorsGastrointestinal SurgeryGastrointestinal MalignancyGastrointestinal TumorsR0 ResectionSmall Bowel Gastrointestinal Stromal TumorsSmall Bowel PerforationSmall Intestinal Gastrointestinal Stromal TumorsSmall Intestinal Neoplasms
A case of perforated gastrointestinal stromal tumor (GIST) of small intestine causing acute abdomen is described, with a brief review of the literature. A male patient presented with symptoms of acute abdomen. After evaluation, a laparotomy was performed, where perforation of a tumor in the ileum was found. The perforated part along with the tumor was resected and the cytopathological examination showed that the tumor was GIST. Postoperatively, the patient received treatment, using imatinib. Gastrointestinal stromal tumors are relatively rare and often present with vague symptoms. Their first clinical manifestation as acute abdomen due to their perforation is extremely rare. In emergency laparotomy, a R0 resection is required and adjuvant therapy with imatinib must be considered.
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Gain-of-Function Mutations of c- <i>kit</i> in Human Gastrointestinal Stromal Tumors
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Two Hundred Gastrointestinal Stromal Tumors
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