PubMed · 1987 · 28 citations · 0 references
MedicinePediatricsPharmacologyPediatric Clinical PharmacologyPediatric EpidemiologyPediatric PharmacotherapyAdverse Drug ReactionsAdverse EffectsPediatric Adverse Drug ReactionsPediatric PharmacologyAdverse Drug Reaction EpidemiologyAntibiotic-associated Adverse ReactionsPolypharmacy-related Adverse ReactionsSerious Adverse Drug Reactions
In accordance with guidelines for a multicentre trial, the incidence and features of adverse drug reactions in a sample of 1327 children attending outpatient consultations have been determined. The incidence was of 0.75% (0.34% - 1.58% with p less than 0.05). The reactions were slight in character and predominantly affected very young female patients. Antibiotics were involved in almost a half of cases, and polypharmacy was used in all of them.