Acta Dermato Venereologica · 1992 · 32 citations · 0 references
MedicineDermatologyImmunologyClinical ImmunologyImmunopathologyImmunopharmacologyAtopic DermatitisImmunopathology Of SkinInflammatory Skin DiseasesInflammatory Skin DisordersInterferon-based TherapyType I HypersensitivityAdverse Treatment EffectsAtopic Dermatitis ImmunopathologyAtopic Dermatitis PharmacotherapyAtopic Dermatitis TreatmentAtopic PatientsImmunologic DysregulationInterferon Alfa TherapyInterferon Alpha-2b Therapy
Thirteen patients with a severe adult form of atopic dermatitis (AD) received 3.0 x 10(6) IU of recombinant interferon-alpha 2a (rIFN-alpha 2a) 3 times a week. A satisfactory response was obtained in 5 of them. Serum IgE levels in all 13 patients remained unchanged throughout the study. Flu-like symptoms were common, but clinical or laboratory adverse effects were otherwise slight. The moderately beneficial therapeutic effects observed in this study support a possible role for IFN-alpha in controlling immunologic deficiencies in atopic dermatitis.