Lupus Nephritis IgG Induction of Calcium/Calmodulin‐Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function

Abstract

LN-derived IgG enters podocytes and up-regulates CAMK4, which is followed by increased expression of genes known to be linked to podocyte damage and T cell activation. Targeted inhibition of CAMK4 in podocytes may prove to be clinically useful in patients with LN.