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Decorin gene transfer inhibited the expression of TGFbeta1 and ECM in rat mesangial cells.

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Citations

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References

2007

Year

Wu F, A Bader, Feilin Dong, Faming Zhu, Wu N, B Wang, Huijun Li, Brockmeyer Nh, P Altmeyer
PubMed

Abstract

The constructed recombinant decorin adenovirus can highly efficiently express biologically active decorin. Overexpression of decorin down-regulates the expression of TGFbeta1 and ECM components from RMCs. These results suggest that overexpression of decorin may be one of the therapeutic approaches to diabetic nephropathy.