Interactions between alpha-adrenergic agents, prostaglandin E1, nicotinic acid, and adenosine in regulation of lipolysis in hamsters epididymal adipocytes.

Abstract

The antilipolytic activity of the alpha-adrenergic agent clonidine was studied using fat cells from the epididymal fat bodies of golden hamsters. Lipolysis activated in a relatively dilute suspension of adipocytes ( 300,000 cells/ml, only 3-isobutyl-1-methylxanthine-accelerated lipolysis was inhibited by clonidine; isoproterenol-activated lipolysis was not. The antilipolytic activity of clonidine toward isoproterenol-activated lipolysis was also lost when adipocytes (