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The antiproliferative effect of coumarins on several cancer cell lines.
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2001
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Chemoprevention StrategyCancer BiologyTumor BiologyOncologyCancer Cell BiologyAnti-cancer AgentRadiation OncologyCancer ResearchAntiproliferative EffectCell Cycle DistributionStructure-activity RelationshipTumor TargetingCancer TreatmentPharmacologyCell BiologyTumor MicroenvironmentPhotocarcinogenesisMedicineTwenty-one Coumarins
Twenty-one coumarins were examined for their antiproliferative activity towards several cancer cell lines, namely lung carcinoma (A549), melanin pigment producing mouse melanoma (B16 melanoma 4A5), human T-cell leukemia (CCRF-HSB-2), and human gastric cancer, lymph node metastasized (TGBC11TKB). The structure-activity relationship established from the results revealed that the 6,7-dihydroxy moiety had an important role for their antiproliferative activity. Analysis of cell cycle distribution indicated that esculetin-treated cells accumulated in the G1 (at 400 microM) or in S phase (at 100 microM).