Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohnʼs Disease Associated with Downregulation of NF-κB Signaling

Abstract

GAC1 inhibited production of TNF-α and other proinflammatory cytokines by PBMCs and inflamed CD colonic mucosa due to blockage of NF-κB activation. GAC1 is a key beneficial constituent in G. lucidum and the Food Allergy Herbal Formula-2 in suppressing the inflammatory cytokines found in CD and warrants clinical investigation for the treatment of CD.