Acta Medica (Hradec Kralove Czech Republic) · 2000 · 18 citations · 6 references
PharmacyPharmacologyPharmacotherapyClinical PharmacologyCost-effectiveness AnalysisPsychopharmacologyAntidepressant PharmacologyAntidepressant PharmacotherapyAntidepressant TherapyDepression ManagementDepression PharmacotherapyMedication UseAntidepressant EfficacyAntidepressant MedicationsDirect CostsHospitalization CostsIntent-to-treat EffectMajor DepressionMedication Therapy Cost AssessmentPrescription Cost Analysis
BACKGROUND: The increasing cost of pharmaceuticals in the Czech Republic has led to the restriction on prescriptions of expensive new antidepressants. The aim of the study was to compare the costs and outcomes of using amitriptyline, citalopram and fluoxetine in the treatment of major depression. METHODS: Ninety patients (69 women) with a mean age of 44.5 years (S.D. = 14.3) suffering from major depression were treated with amitriptyline (N = 31), citalopram (N = 29) and fluoxetine (N = 30). Direct medical costs and effectiveness (indicated by the number of hospitalization-free days) were assessed in a prospective, open, intent-to-treat study. RESULTS: Neither cost nor effectiveness were significantly different among the treatment groups. CONCLUSION: Amitriptyline treatment is not less expensive nor more effective than citalopram or fluoxetine therapies. There is no advantage in restricting patients from treatment with SSRIs, which have fewer adverse effects and a decreased risk of a lethal overdosage in comparison with tricyclic antidepressants.
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Bengt Jönsson, Paul Bebbington · The British Journal of Psychiatry · 1994 · 228 citations
Paul Kind · International Clinical Psychopharmacology · 1993 · 136 citations