Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in salivary glands of patients with Sjögren's syndrome. - Concepedia

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Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in salivary glands of patients with Sjögren's syndrome.

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Citations

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References

2007

Year

Chiyo Kurimoto, Seiji Kawano, Goh Tsuji, Saori Hatachi, Takumi Jikimoto, Daisuke Sugiyama, Shimpei Kasagi, Takahide Komori, Hajime Nakamura, Junji Yodoi,

Abstract

Parallel production of oxidative stress markers together with massive secretion of TRX suggests that oxidative stress induces TRX in the salivary gland. Moreover, suppression of IL-6 production and apoptosis by rTRX in HSG cells suggests TRX acts to protect the salivary glands of SS patients from tissue damage.