Prognosis of Tropical Sprue

Abstract

Article1 December 1962Prognosis of Tropical SprueA Study of the Effect of Folic Acid on the Intestinal Aspects of Acute and Chronic SprueTHOMAS W. SHEEHY, M.D., F.A.C.P., BARBARA BAGGS, B.S., M.A., ENRIQUE PEREZ-SANTIAGO, M.D., MARTIN H. FLOCH, M.D.THOMAS W. SHEEHY, M.D., F.A.C.P.Search for more papers by this author, BARBARA BAGGS, B.S., M.A.Search for more papers by this author, ENRIQUE PEREZ-SANTIAGO, M.D.Search for more papers by this author, MARTIN H. FLOCH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-6-892 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUntreated tropical sprue is a chronic unrelenting disease characterized by diarrhea, weight loss, weakness, and eventually by severe anemia and emaciation. Without therapy, frequent relapses occur and the disease may terminate in invalidism or death from inanition, intercurrent disease, or a semi-choleraic attack (1, 2). The advent of liver therapy and, later, of folic acid altered this grim prognosis and provided a therapeutic means of returning most patients with tropical sprue to gainful activity. Indeed, the remarkable effect of folic acid or vitamin B12therapy and, in some cases, of broad spectrum antibiotics led some to consider the disease to...References1. MANSON-BAHR PH: Manson's Tropical Disease, 15th Ed., ed. by Manson-Bahr, P. H., The Williams & Wilkins Company, Baltimore, 1956. Google Scholar2. CASTLERHOADSLAWSONPAYNE WBCPHAGC: Etiology and treatment of sprue. Arch. Intern. Med. 56: 627, 1935. CrossrefGoogle Scholar3. DONIACHSHINER IM: Malabsorption syndromes: a symposium. V. Histopathology of the stomach in pernicious anemia and the jejunum in steatorrhea. Brit. J. Radiol. 33: 238, 1960. CrossrefMedlineGoogle Scholar4. 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SCHENK, M.D.Peroral Biopsy of the Small IntestineLong-term Antibiotic Therapy in Tropical SprueRICARDO GUERRA, M.D., MUNSEY S. WHEBY, THEODORE M. BAYLESS, M.D.The Jejunal Mucosa in Patients with Nutritional Folate Deficiency and Megaloblastic AnemiaTropical Sprue in New York CityTransient Selective Vitamin B12 Malabsorption in an AdultWALTER J. HOGAN, M.D., KONRAD H. SOERGEL, M.D., SARA B. ARNAUD, M.D.Intestinal biopsy in acute hepatitisThe intestinal lesion in the initial phase of tropical (Military) sprue 1 December 1962Volume 57, Issue 6Page: 892-908KeywordsAntibioticsDiarrheaDysenteryFolic acidLesionsLiverMucous membranesResearch laboratoriesTropical diseasesWeight loss ePublished: 1 December 2008 Issue Published: 1 December 1962 PDF downloadLoading ...