Studies on the ketogenic activity of the anterior pituitary

Abstract

BuRN & LiN [1930] were the first to demonstrate that the injection of anterior pituitary extracts into normal fasting rats is followed by an increased urinary excretion of acetone bodies. This observation has been repeatedly confirmed in the rat and a similar increase in the urinary excretion of these substances has also been found in the dog [Rietti, 1934] and guinea pig [Best & Campbell, 1938]. As may be anticipated there also occurs in susceptible animals a simultaneous increase in the blood acetone bodies and this has been found in the rat, dog, man [