DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling

Abstract

These results indicate that DUSP8 controls basal and acute stress-induced extracellular signal-regulated kinases 1/2 signaling in adult cardiac myocytes that then alters the length-width growth dynamics of individual cardiac myocytes, which further alters contractility, ventricular remodeling, and disease susceptibility.