Concepedia

CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia

Nadine Haase, Michaela Golić, Julianna Rugor, María Emilia Solano, Petra Arck, Martin Gauster, Berthold Huppertz, Christoph Emontzpohl, Christian Stoppe, Jürgen Bernhagen,

Circulation Research · 2016 · 91 citations · 42 references

DOIFull text

Open access

Abstract

CD74 downregulation in placental macrophages is present in preeclampsia. CD74 downregulation leads to altered macrophage activation toward a proinflammatory signature and a disturbed crosstalk with trophoblasts.

References

42

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

Sharon E. Maynard, Jiang-Yong Min, Jaime R. Merchan et al. · Journal of Clinical Investigation · 2003 · 3.9K citations · Full text

, , +22

Hypertension in Pregnancy

Obstetrics and Gynecology · 2013 · 3.9K citations

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Evaluation of High-Sensitivity C-Reactive Protein and Serum Lipid Profile in Southeastern Nigerian Women with Pre-Eclampsia

Anaelechi J. Onuegbu, Japhet M. Olisekodiaka, John U. Udo et al. · Medical Principles and Practice · 2015 · 2K citations · Full text

Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis

Gavin Sacks, K. Studená, Ian L. Sargent et al. · American Journal of Obstetrics and Gynecology · 1998 · 831 citations

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Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array

András Szarka, János Rigó, Levente Lázár et al. · BMC Immunology · 2010 · 515 citations · Full text