Publication | Closed Access
New [(η<sup>5</sup>-C<sub>5</sub>H<sub>5</sub>)Ru(N–N)(PPh<sub>3</sub>)][PF<sub>6</sub>] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes
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Citations
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References
2016
Year
Pharmaceutical ScienceChemoprevention StrategyGlycobiologyColon Anticancer ActivityRuthenium GlycoconjugatesCarbohydrate-appended ComplexesPharmaceutical ChemistryTumor BiologyMolecular PharmacologyMedicinal ChemistryGlut-mediated Cellular UptakeGlucose TransportersCellular UptakeAnti-cancer AgentBiochemistryTumor TargetingPharmacologyNatural SciencesMedicineCarbohydrate-protein InteractionDrug Discovery
Eight ruthenium(ii) compounds of the general formula [(η(5)-C5H5)Ru(N-N)(PPh3)][PF6] were rationally designed, exhibiting high cytotoxicity against HCT116 human colon cancer cells, with IC50 between 14.56 and 1.56 μM; importantly, compounds 5Ru and 6Ru are the first reported ruthenium glycoconjugates exploiting glucose transporters, widely overexpressed in cancer, for cellular uptake.
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