Mesalazine Changes Apoptosis and Proliferation in Normal Mucosa of Patients with Sporadic Polyps of the Large Bowel

Abstract

Mesalazine significantly induces apoptosis and decreases proliferation in colorectal mucosa in patients with sporadic polyps of the large bowel. This may be clinically relevant in that it may lower the rate of polyp recurrence after polypectomy, thereby possibly contributing to the chemoprevention of sporadic colorectal carcinoma.