Recent Advances in Ophthalmic Drug Delivery System

Abstract

Due to the complexity of ocular physiological structure and the existence of numerous barriers,many drugs have little effect on the eye diseases.To improve the therapy efficacy of ophthalmic drugs,colloidal systems(including nanosuspensions,liposomes,micro-/nano- emulsions,fat emulsions and nanoparticles),in situ gel and solid preparation for ophthalmic delivery are adopted to prolong drug corneal retention and reduce the systemic absorption.This paper reviews the recent advances of above drug delivery systems,but also points out some obstacles.