An instrument and method for automatic, rapid, accurate, and sensitive titration of chloride in biologic samples.

Abstract

Abstract An instrument and method are described which provide accurate, rapid, and automatic analysis of chloride in biologic samples, by electrometric titration with silver ion. Titrations times of 20 to 60 seconds per sample have a standard deviation of about 0.5 per cent of the mean value, and shorter times down to 5 seconds have only slightly greater variability. The method is sensitive, measuring accurately as little as 0.25 μEq of chloride. Operation of the instrument is simple and can be performed by personnel with little experience. Preparation of plasma, urine, or water extracts of tissue for titration requires only addition of reagent.