[Malignant granular cell tumor: a clinicopathologic analysis of 10 cases with review of literature].

Abstract

The histologic criteria for malignancy in GCTs established in 1998 by Fanburg-Smith et al. are reproducible in most instances. In exceptional circumstances, however, the diagnosis relies on clinicopathologic correlation. Based on the current study and literature review, a modified criterion of mitotic count (> 5/50 HPF instead of > 2/10 HPF) is recommended. Wide local excision with regional lymph node dissection remains the mainstay of treatment. Chemotherapy and radiotherapy however have not been shown to significantly improve the clinical course of the disease. The morphologic spectrum of MGCT also includes a rare multinucleated variant.