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A COMPARATIVE STUDY OF NUCLEOTROPOMYOSINS FROM DIFFERENT SOURCES
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1954
Year
Muscle FunctionMolecular BiologyCytoskeletonAnatomyReproductive BiologyBovine Foetal MusclesEmbryologyReproductive PhysiologyUnicellular OrganismBiosynthesisSkeletal MuscleBiochemical TaxonomySmooth MusclesAnimal PhysiologyBiochemistryBovine UterusEmbryonic DevelopmentEndocrinologyBiologyDevelopmental BiologyAnimal ScienceNatural SciencesPhysiologyMedicine
A general method is described for the efficient isolation of crystallisable nucleotropomyosins from all types of muscle-skeletal, cardiac and smooth. In all preparations the nucleic acid moiety is of the pentose type. The smooth muscles of the duck gizzard contain 1.1%(wet weight) of this protein, which is about 2-6 times the content in all the vertebrate and crustacean skeletal muscles investigated. Nucleotropomyosins of the non-gravid cow uterus, of the pig heart and of the crab contain up to 16% nucleic acid. Throughout the course of pregnancy, the nucleotropomyosin content of the bovine uterus remains relatively constant, nor is there any perceptible change in the amount of this protein in bovine foetal muscles during the later stages of embryonic development. A tentative suggestion is made that, of the dual functions of muscle, those of contraction and of holding, tropomyosin may be the substrate for the latter.