Concepedia

Publication | Open Access

Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment

DOIFull Paper Access

80

Citations

25

References

2015

Year

Vasileios Askoxylakis, Gino B. Ferraro, David P. Kodack, Mark Badeaux, Ram C. Shankaraiah, Giorgio Seano, Jonas Kloepper, Trupti D. Vardam, John D. Martin, Kamila Naxerova,
JNCI Journal of the National Cancer Institute

Abstract

T-DM1 can overcome resistance to trastuzumab therapy in HER2-driven or PI3K-driven breast cancer brain lesions due to the cytotoxicity of the DM1 component. Clinical investigation of T-DM1 for patients with CNS metastases from HER2-positive breast cancer is warranted.

References

YearCitations

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