HEPATOPROTECTIVE EFFECT OF PLUMBAGO ZEYLANICA ON PARACETAMOL INDUCED LIVER TOXICITY IN RATS

Abstract

Petroleum ether extract of root of Plumbago zeylanica was investigated for hepatoprotective activity against paracetamol induced liver damage. Various biochemical parameters were studied to evaluate the hepatoprotective activity of ethanolic extract.  In serum total bilirubin, total protein, aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, γ‐Glutamyl transferase, Total Cholesterol and serum triglycerides were determined to assess the effect of the extract on the paracetamol induced hepatic damage.  The study was also supported by histopathology of liver sections. Results of this study revealed that the markers in the animals treated with paracetamol recorded elevated concentration indicating severe hepatic damage by paracetamol, whereas the blood samples from the animals treated with petroleum ether extract of roots showed significant reduction in the serum markers indicating the effect of the plant extract in restoring the normal functional ability of the hepatocytes.  The dosage of extract of plant roots used was 300 mg/kg bodyweight of rat.  The present study reveals that the petroleum ether root extract of Plumbago zeylanica could afford a significant protection against paracetamol‐induced hepatocellular injury.