American Journal of Clinical Oncology · 1983 · 13 citations · 0 references
MedicineOncologySurgeryChemotherapyMedical OncologyPediatric OncologyBone TumorsMalignant NeoplasmsPediatric ChemotherapyPediatric SarcomasPediatric TumorsRadiation TherapyChemotherapy For Bone TumorsChemotherapy-associated Surgical ComplicationsChemotherapy-related ToxicityOsteosarcoma ChemotherapyOsteosarcoma SurgeryOsteosarcoma TreatmentPediatric Bone SarcomasRadiation-induced Second Malignancies
Prolonged, aggressive chemotherapy of advanced Hodgkin's disease carries the risk of second malignancies. Two teenage patients developed osteosarcoma at sites far removed from any radiation portal following chemotherapy for Hodgkin's disease.