Chemischer Informationsdienst · 1986 · 16 citations · 1 references
PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryStructural BiochemistryAnemiaHemoglobin PhysiologyLigand BindingProtein BindingSickle Cell DiseaseStructure-activity Relationship AnalysisDiuretic InteractionsHemoglobin StructureSickle Cell Anemia
Abstract In an attempt to establish a stereochemical rationale for the development of drugs against sickle cell anemia, human deoxyhemoglobin has been crystallized with the antihyperlipoproteinemia drug beza?brate (I), with the diuretic drug ethacrynic acid (II), with the succinyl‐dipeptide (III), and with the acid (IV), and the structures of the complexes formed have been determined by X‐ray analysis (detailed discussion).
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