Concepedia

Intraocular Pharmacokinetics of Intravitreal Aflibercept (Eylea) in a Rabbit Model

Sang Jun Park, Yewon Choi, Young Mi Na, Hye Kyoung Hong, Ji Yeon Park, Kyu Hyung Park, Jae‐Yong Chung, Se Joon Woo

Investigative Ophthalmology & Visual Science · 2016 · 93 citations · 11 references

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Abstract

In rabbits, the vitreous half-life of aflibercept is 94.1 hours (3.92 days). This is shorter than that of bevacizumab (6.99 days), and longer than that of ranibizumab (2.51 days) and VEGF-Trap (3.63 days).

References

11

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Jocelyn Holash, Sam Davis, Susan D. Croll et al. · Proceedings of the National Academy of Sciences · 2002 · 1.7K citations · Full text

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Predicted biological activity of intravitreal VEGF Trap

Michael W. Stewart, Philip J. Rosenfeld · British Journal of Ophthalmology · 2008 · 371 citations

Pharmacokinetics of Bevacizumab after Topical, Subconjunctival, and Intravitreal Administration in Rabbits

Hiroyuki Nomoto, Fumio Shiraga, Noriyuki Kuno et al. · Investigative Ophthalmology & Visual Science · 2009 · 273 citations

PHARMACOKINETICS AND RETINAL DISTRIBUTION OF RANIBIZUMAB, A HUMANIZED ANTIBODY FRAGMENT DIRECTED AGAINST VEGF-A, FOLLOWING INTRAVITREAL ADMINISTRATION IN RABBITS

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Distinct Aggregation Mechanisms of Monoclonal Antibody Under Thermal and Freeze-Thaw Stresses Revealed by Hydrogen Exchange

Aming Zhang, Satish Kumar Singh, Michael R. Shirts et al. · Pharmaceutical Research · 2011 · 151 citations

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