EXPERIMENTAL STUDY OF IN VIVO IMPLANTATION OF A MAGNESIUM ALLOY AT EARLY STAGE

Abstract

In order to study both the effect and the degradation behavior of magnesium alloys on/in animals,AZ31B magnesium alloys with different dimensions were implanted in the New-Zealand rabbits,and compared with a titanium alloy(Ti-6Al-4V)as a control material.It was found from the experiments that the osteotylus was formed surround the magnesium alloy,implant after 2 weeks,which was turned into ripe bone tissue after 8 weeks.The implantation of the magnesium alloy did not show negative influence on the recirculating,immune and urinary systems of the rabbits.Magnesium calcium apatite,which was the main degradation product of the magnesium alloy,could be metabolismed by the kidney.Magnesium ion concentration in the blood was in the range of normal values.It can be concluded that the magnesium alloy implantation is safe for rabbits at the early stage,and the implant can be beneficial to the new bone formation.