Evaluation of anti-inflammatory,analgesic and antipyretic actions for the extracts from Radix Tetrastigmae

Abstract

Objective:To study the anti-inflammatory,analgesic and antipyretic actions of the extracts of Radix Tetrastigmae(ERT).Methods:The anti-inflammatory action was assessed by several tests including HAc-induced peritoneal capillary permeability in mice, xylene-induced ear edema in mice and albumin-induced paw edema in rats. The analgesic effect was verified by HAc-induced writhing response in mice and hot-plate test. The antipyretic action was monitored by dried yeast-induced and 2,4-dinitrophenol-induced pyrexia.Results:The ERT significantly inhibited the phlogistic infiltration in mice, and improved the ear edema in mice and the paw edema in rats. The ERT mice showed fewer writhes of abdominal cavity,and increased the pain threshold in the hot-plate test. The fever induced by dried yeast and 2,4-dinitrophenol was reduced by the ERT.Conclusion:ERT has anti-inflammatory,analgesic and antipyretic actions, which is coincident with the clinical indications of Radix Tetrastigmae in the viewpoints of the Chinese Traditional Medicine.