Calcineurin Orchestrates Lateral Transfer of <i>Aspergillus fumigatus</i> during Macrophage Cell Death

Abstract

These observations identify programmed, necrosis-dependent lateral transfer of A. fumigatus between macrophages as an important host strategy for controlling fungal germination. This process is critically dependent on calcineurin. Our studies provide fundamental insights into the pathogenesis of pulmonary aspergillosis in the immunocompromised host.