Functional connectivity underpinnings of fatigue in “ <i>D</i> rug <i>‐Naïve</i> ” patients with Parkinson's disease

Abstract

Our findings revealed that primary PD-related fatigue is associated with an altered default mode network and sensorimotor network connectivity in drug-naïve patients. We hypothesize that these divergent motor and cognitive networks connectivity changes and their adaptive or maladaptive functional outcome may play a prominent role in the pathophysiology of fatigue in PD. © 2016 International Parkinson and Movement Disorder Society.