Concepedia

Publication | Open Access

Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for<i>IDH1</i>mutant glioma

DOIFull Paper Access

73

Citations

32

References

2016

Year

Hiroaki Nagashima, Kazuhiro Tanaka, Takashi Sasayama, Yasuhiro Irino, Naoko Sato, Katsusuke Kyotani, Akitake Mukasa, Katsu Mizukawa, Junichi Sakata, Yusuke Yamamoto,
Neuro-Oncology

Abstract

IDH1 mutations alter glutamate metabolism. Combining glutamate levels optimizes the 2HG-based monitoring of IDH1 mutations via MRS and represents a reliable clinical application for diagnosing IDH1 mutant gliomas.

References

YearCitations

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