Molecular mechanisms of diabetic coronary dysfunction due to large conductance Ca2⁺-activated K⁺ channel impairment. - Concepedia

Concepedia

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Molecular mechanisms of diabetic coronary dysfunction due to large conductance Ca2⁺-activated K⁺ channel impairment.

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References

2012

Year

Ru Xinsg Wang, Haifeng Shi, Qiang Chai, Ying Wu, Wei Sun, Yuan Ji, Yong Yao, Ku Lin Li, Chang Ying Zhang, Jie Zheng,

Abstract

Our results indicated that BK channels are the key determinant of coronary arterial tone. Impaired BK channel function in diabetes mellitus is associated with down-regulation of BK-b(1) expression and reduction of the b(1)-mediated BK channel activation in diabetic vessels.