Temperature Tracking in a Three-Dimensional Matrix Using Thermosensitive Liposome Platform

Abstract

Thermosensitive lipid-based nanoparticle (liposome) is a key platform for the controlled release of functional molecules by regional heating. Temperature monitoring in a three-dimensional matrix is necessary to conduct controlled heating at the targeted region. Currently, conventional liposomes do not possess a function for temperature monitoring. Herein, an extended concept for temperature monitoring using the liposomes was examined using near-infrared (NIR) laser-induced heating of water in hydrogel. The temperature distribution in hydrogel by photothermal conversion can now be traced by fluorescence in real time, with the use of liposomes that release the fluorescence cargo at different threshold temperatures. The liposome platform, equipped with temperature-sensing capability, extend the concept of temperature monitoring for temperature-triggered drug release, as well as thermotherapy.