Concepedia

A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart

Randell C. Thomas, Abhishek Singh, Patrick M. Cowley, Bat‐Erdene Myagmar, Megan D. Montgomery, Philip M. Swigart, Teresa De Marco, Anthony J. Baker, Paul Simpson

JACC Basic to Translational Science · 2016 · 37 citations · 27 references

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Abstract

We have developed a simple, high throughput LV myocardial slice culture model to study signaling in the human heart. This model can be useful for translational studies, and we show for the first time that the alpha-1A-AR is functional in signaling and contraction in the human heart.

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