Elevated local [Ca²⁺] and CaMKII promote spontaneous Ca²⁺release in ankyrin-B-deficient hearts

Abstract

The increased incidence of pro-arrhythmogenic Ca(2+) sparks and waves in AnkB(+/-) hearts is due to enhanced CaMKII-mediated RyR phosphorylation, which is caused by higher junctional [Ca(2+)] and consequent local CaMKII activation.