Inflammatory cytokines induce caveolin‐1/β‐catenin signalling in rat nucleus pulposus cell apoptosis through the p38 <scp>MAPK</scp> pathway

Abstract

The results revealed the role of p38/caveolin-1/β-catenin in inflammatory cytokine-induced apoptosis in rat NP cells. Thus, controlling p38/caveolin-1/β-catenin activity seemed to regulate IL-1β- and TNF-α-induced apoptosis in the NP during intervertebral disc degeneration.