Comparison of the radiotoxicity of the ^99mTc-labeled compounds ^99mTc-pertechnetate, ^99mTc-HMPAO and ^99mTc-MIBI

Abstract

Our findings reveal that clonogenic cellular survival is not solely determined by the DNA-DSB response. This finding may suggest the involvement of extra-nuclear radiosensitive targets in cell inactivation. For example, the mitochondria or the cell membrane could be affected by ^99mTc-HMPAO.