A Short-Term Clinical Evaluation of L-697,661, a Non-Nucleoside Inhibitor of HIV-1 Reverse Transcriptase - Concepedia

Concepedia

Publication | Open Access

A Short-Term Clinical Evaluation of L-697,661, a Non-Nucleoside Inhibitor of HIV-1 Reverse Transcriptase

DOI Full Paper Access

147

Citations

35

References

1993

Year

Michael S. Saag, Emilio A. Emini, Oscar L. Laskin, Jeffrey A. Douglas, William I. Lapidus, William A. Schleif, Richard J. Whitley, CAROL S. HILDEBRAND, V W Byrnes, John C. Kappes,

New England Journal of Medicine

Abstract

L-697,661 is safe and well tolerated and has significant dose-related activity against HIV-1. However, resistant strains of the virus emerge rapidly and may limit the effectiveness of non-nucleoside reverse transcriptase inhibitors as monotherapy for HIV-1 infection.

References

	Year	Citations

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