Effects of a single, large, intravenous iniection of dexamethasone

Abstract

In a double‐blind study, 60 normal adult volunteers were infused with 2.0 mg. per kilogram of dexamethasone disodium phosphate or an equal amount of the diluent. The men and women receiving dexamethasone complained within 2 minutes of itching, burning, or tingling, all of which were most intense in the anogenital area, and which subsided within minutes. Prolonging the infusion time minimized or prevented this complaint.