PubMed · 1993 · 17 citations · 0 references
MedicineNuclear MedicineRadiologyDiagnostic ImagingDiagnostic Nuclear MedicineDiagnostic RadiologyHyperthyroidism EvaluationThyroid ImagingThyroid Nodule EvaluationThyroid ScintigraphyThyroid UltrasonographyThyroid Uptake StudiesClinical Assessment Of HyperthyroidismMann - Whitney U TestQuantitative Uptake RatiosRadionuclide Thyroid ScintigraphyTechnetium-99m Pertechnetate Thyroid ImagingThyroid Function EvaluationThyroid Radionuclide UptakeThyroid Uptake Kinetics
Ten normal volunteers and 14 patients with hyperthyroidism had pinhole thyroid imaging 30 min after an intravenous injection of 10 mCi 99mTc-MIBI. Technetium-99m-MIBI thyroid uptake was calculated by the formula: [total counts with a region of interest (ROI) over the whole thyroid gland] divided by [(mean counts of every pixel in the neck soft tissue) x (total number of pixels in ROI over the whole thyroid gland)]. The results showed that the 30 min 99mTc-MIBI thyroid uptake ratios had positive relationships with the 24 hr 131I-thyroid uptake (r = 0.79), and that the patients with hyperthyroidism had significantly higher 30 min 99mTc-MIBI thyroid uptake than the normal volunteers (5.31 +/- 0.78 s.e.m. versus 2.35 +/- 0.14 s.e.m., p < 0.005 using the Mann-Whitney U-test). Technetium-99m-MIBI thyroid uptake may be useful for the rapid diagnosis of hyperthyroidism.