Cerebrospinal fluid levels of insulin, leptin, and agouti‐related protein in relation to BMI in pregnant women

Abstract

High serum AgRP levels might protect from the suppressive effects of leptin during pregnancy. Pregnant women with OB and OW might further be protected from the suppressive effect of leptin by high CSF AgRP levels. Evidence was found, for the first time, of human placental AgRP production mirrored by levels in the circulation.