Antitumor activity of Vitex negundo Linn. against Dalton's Ascitic Lymphoma.

Abstract

The aim of the present study is to evaluate the effect of ethanolic (EEVN) and aqueous (AEVN) extract of leaves of Vitex Negundo Linn. Against Dalton’s Ascitic Lymphoma (DAL) in Swiss Albino mice. DAL cells were injected intraperitoneally (1× 10 cells) to the each mice. Two days after cells injection the animals were treated with 200 mg/kg of ethanolic extract of Vitex negundo (EEVN) and aqueous extract of Vitex negundo (AEVN) for 14 days. 5 fluorouracil (20 mg/kg) was used as standard drug. The entire animals were evaluated for Median Survival Time (MST), and Cancer cell count, packed cell volume, Hematological parameters was compared with the same parameters in standard by collecting blood from retro orbital blood vessel of mice. All the parameters were normalized in tumorinduced mice. These observations suggest that both the extract (EEVN and AEVN) posses antitumor effect against Dalton’s Ascitic Lymphoma (DAL).