Thrombin Augments LPS‐Induced Human Endometrial Endothelial Cell Inflammation via PAR1 Activation

Abstract

Thrombin, via PAR1 activation, synergistically augments LPS-induced HEEC production of chemokines involved in immune cell recruitment and survival, suggesting a mechanism by which intrauterine abruption and bacterial infection may together be associated with an aggravated uterine inflammatory response.