Effects of Unbuffered and Buffered Acetylsalicylic Acid on Intragastric pH

Abstract

IN spite of the widespread clinical use of acetylsalicylic acid in both buffered and unbuffered preparations, there is little information in the voluminous literature concerning the pharmacologic effects of the drug on gastric acidity in man.Schnedorf, Bradley and Ivy1 reviewed the literature and found no conclusive evidence that acetylsalicylic acid affected gastric acidity in man. In their own studies, however, they reported that doses of 1 to 2 gm. increased the total titratable acidity per milliliter of gastric aspirate by 27 to 58 per cent. A decrease in total acidity was observed when 3 gm. of sodium bicarbonate was . . .