Sickling of Erythrocytes in a Patient with Thalassemia-Hemoglobin-I Disease

Abstract

IN 1955 Rucknagel et al.1 described a new abnormal hemoglobin in a Negro family in North Carolina. This hemoglobin, designated "I", migrated more rapidly than normal hemoglobin on filter-paper electrophoresis at pH 8.6, and constituted about 20 per cent of the total hemoglobin present. The following report concerns a patient with a similar I-A electrophoretic hemoglobin pattern in whom the I hemoglobin constitutes 70 per cent of the total hemoglobin. Despite the absence of S hemoglobin in the red cells of this patient, the sodium metabisulfite sickling test was found to be positive.2 Clinical DataJ.W., a twenty-five-year-old Negro woman, . . .