Effects of High-Volume Continuous Hemofiltration on Experimental Pancreatitis Associated Lung Injury in Pigs

Abstract

CVVH can reduce pulmonary edema and the severity of PALI in pigs with high-volume CVVH being significantly better than low-volume CVVH. The beneficial effects of CVVH on arterial oxygenation and pulmonary function may be connected with improvements in systemic hemodynamics, reduction in plasma cytokine concentration and decreased activity of NF- ê B in peripheral blood mononuclear cells.